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| Name | 1-Hexane Sulfonic Acid Sodium Salt |
| Type | Product for HPLC (High Performance Liquid Chromatography) |
| Formula | C6H13NaO3S |
| Molar Mass | 194.22 g/mol |
| CAS Number | 28348-53-0 |
| Appearance | White to off-white powder |
| Solubility | Soluble in water |
| Storage | Store at room temperature |
| Purity | ≥ 98% |
| Synonyms | Sodium n-hexanesulfonate |
| Hazard Statements | Not classified as hazardous |
FAQ
What is 1-Hexane Sulfonic Acid Sodium Salt and its application in HPLC?
1-Hexane Sulfonic Acid Sodium Salt is a strong anionic surfactant commonly used in High-Performance Liquid Chromatography (HPLC) as an ion-pairing reagent. It helps improve the chromatographic separation of polar and ionizable compounds by forming ion pairs with analytes of interest that would otherwise not be retained by the stationary phase of the column.
How does 1-Hexane Sulfonic Acid Sodium Salt improve HPLC performance?
By forming ion pairs with analytes, 1-Hexane Sulfonic Acid Sodium Salt can enhance the retention of polar compounds on the stationary phase of the column, leading to improved peak shape, resolution, and sensitivity in HPLC separation. It also helps to reduce tailing and broaden peaks caused by non-specific interactions with the column or sample matrix.
What are the advantages of using 1-Hexane Sulfonic Acid Sodium Salt in HPLC?
Some of the key benefits of using 1-Hexane Sulfonic Acid Sodium Salt in HPLC include:
- Improved separation of polar and ionizable compounds
- Enhanced peak shape, resolution, and sensitivity
- Reduction of tailing and peak broadening
- Compatibility with a wide range of analytical methods and detection techniques
- Cost-effective option for optimizing HPLC performance
How should 1-Hexane Sulfonic Acid Sodium Salt be used in HPLC applications?
1-Hexane Sulfonic Acid Sodium Salt is typically added to the mobile phase in HPLC at concentrations ranging from 1-20 mM depending on the specific analytical requirements. It is important to optimize the concentration of the ion-pairing reagent based on the nature of the analytes and the chromatographic conditions to achieve the desired separation and detection.
Are there any specific considerations when using 1-Hexane Sulfonic Acid Sodium Salt in HPLC?
While 1-Hexane Sulfonic Acid Sodium Salt is generally considered safe for use in HPLC, it is important to be mindful of potential interactions with other components in the mobile phase, such as buffers or additives, that may affect the performance of the chromatographic system. It is recommended to conduct method development and validation experiments to ensure optimal conditions for the specific analytes of interest.
1-Hexane Sulfonic Acid Sodium Salt is a strong anionic surfactant commonly used in High-Performance Liquid Chromatography (HPLC) as an ion-pairing reagent. It helps improve the chromatographic separation of polar and ionizable compounds by forming ion pairs with analytes of interest that would otherwise not be retained by the stationary phase of the column.
How does 1-Hexane Sulfonic Acid Sodium Salt improve HPLC performance?
By forming ion pairs with analytes, 1-Hexane Sulfonic Acid Sodium Salt can enhance the retention of polar compounds on the stationary phase of the column, leading to improved peak shape, resolution, and sensitivity in HPLC separation. It also helps to reduce tailing and broaden peaks caused by non-specific interactions with the column or sample matrix.
What are the advantages of using 1-Hexane Sulfonic Acid Sodium Salt in HPLC?
Some of the key benefits of using 1-Hexane Sulfonic Acid Sodium Salt in HPLC include:
- Improved separation of polar and ionizable compounds
- Enhanced peak shape, resolution, and sensitivity
- Reduction of tailing and peak broadening
- Compatibility with a wide range of analytical methods and detection techniques
- Cost-effective option for optimizing HPLC performance
How should 1-Hexane Sulfonic Acid Sodium Salt be used in HPLC applications?
1-Hexane Sulfonic Acid Sodium Salt is typically added to the mobile phase in HPLC at concentrations ranging from 1-20 mM depending on the specific analytical requirements. It is important to optimize the concentration of the ion-pairing reagent based on the nature of the analytes and the chromatographic conditions to achieve the desired separation and detection.
Are there any specific considerations when using 1-Hexane Sulfonic Acid Sodium Salt in HPLC?
While 1-Hexane Sulfonic Acid Sodium Salt is generally considered safe for use in HPLC, it is important to be mindful of potential interactions with other components in the mobile phase, such as buffers or additives, that may affect the performance of the chromatographic system. It is recommended to conduct method development and validation experiments to ensure optimal conditions for the specific analytes of interest.
