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| Name | N-Methyl-N-(Trimethylsilyl) Trifluoroacetamide |
| Abbreviation | MSTFA |
| Molecular Formula | C8H18F3NOSi |
| Molecular Weight | 221.32 g/mol |
| CAS Number | 24589-78-4 |
| Appearance | Colorless liquid |
| Boiling Point | 100-105°C |
| Density | 0.868 g/cm3 |
| Solubility | Insoluble in water, soluble in organic solvents |
| Purity | ≥ 99% |
| Usage | Silylating agent for gas chromatography |
| Storage Conditions | Store in a cool, dry place away from light |
| Pubchem Id | 31305 |
FAQ
What is N-Methyl-N-(Trimethylsilyl) Trifluoroacetamide (MSTFA) and how is it used in Gas
Chromatography (GC)?
N-Methyl-N-(Trimethylsilyl) Trifluoroacetamide, also known as MSTFA, is a popular derivatization reagent used in Gas Chromatography (GC) to enhance the analysis of various compounds. It is commonly used to silylate polar compounds, making them more volatile and thermally stable, which allows for better resolution and detection in the GC system.
What are the key benefits of using MSTFA for GC derivatization?
One of the key benefits of using MSTFA for GC derivatization is its ability to derivatize a wide range of compounds, including alcohols, amines, and acids. It also offers fast derivatization kinetics, which can significantly reduce sample preparation time. Additionally, MSTFA derivatization results in stable derivatives that are compatible with GC systems and provide excellent peak shape and resolution.
How can MSTFA be used in combination with other derivatization reagents in GC analysis?
MSTFA can be used in combination with other derivatization reagents in GC analysis to achieve specific derivatization goals. For example, MSTFA can be used in combination with BSTFA to silylate compounds with different functional groups simultaneously. By carefully selecting the appropriate derivatization reagents and conditions, analysts can optimize the derivatization process for their specific analytical needs.
What are some common applications of MSTFA in GC analysis?
MSTFA is commonly used in a wide range of applications in GC analysis, including the analysis of fatty acids, steroids, amino acids, and other polar compounds. It is particularly useful for analyzing complex mixtures where derivatization is necessary to improve compound volatility and stability. MSTFA is also widely used in metabolomics, environmental analysis, and forensic analysis, among other fields.
How can MSTFA help improve the sensitivity and reliability of GC analysis?
By derivatizing polar compounds with MSTFA, analysts can improve the sensitivity and reliability of GC analysis by enhancing compound detectability and stability. MSTFA derivatization can increase compound volatility, reduce matrix effects, and improve peak resolution, ultimately leading to more accurate and precise analytical results. In addition, MSTFA derivatization can help minimize unwanted interactions between compounds and GC columns, resulting in a more robust and reproducible analytical method.
N-Methyl-N-(Trimethylsilyl) Trifluoroacetamide, also known as MSTFA, is a popular derivatization reagent used in Gas Chromatography (GC) to enhance the analysis of various compounds. It is commonly used to silylate polar compounds, making them more volatile and thermally stable, which allows for better resolution and detection in the GC system.
What are the key benefits of using MSTFA for GC derivatization?
One of the key benefits of using MSTFA for GC derivatization is its ability to derivatize a wide range of compounds, including alcohols, amines, and acids. It also offers fast derivatization kinetics, which can significantly reduce sample preparation time. Additionally, MSTFA derivatization results in stable derivatives that are compatible with GC systems and provide excellent peak shape and resolution.
How can MSTFA be used in combination with other derivatization reagents in GC analysis?
MSTFA can be used in combination with other derivatization reagents in GC analysis to achieve specific derivatization goals. For example, MSTFA can be used in combination with BSTFA to silylate compounds with different functional groups simultaneously. By carefully selecting the appropriate derivatization reagents and conditions, analysts can optimize the derivatization process for their specific analytical needs.
What are some common applications of MSTFA in GC analysis?
MSTFA is commonly used in a wide range of applications in GC analysis, including the analysis of fatty acids, steroids, amino acids, and other polar compounds. It is particularly useful for analyzing complex mixtures where derivatization is necessary to improve compound volatility and stability. MSTFA is also widely used in metabolomics, environmental analysis, and forensic analysis, among other fields.
How can MSTFA help improve the sensitivity and reliability of GC analysis?
By derivatizing polar compounds with MSTFA, analysts can improve the sensitivity and reliability of GC analysis by enhancing compound detectability and stability. MSTFA derivatization can increase compound volatility, reduce matrix effects, and improve peak resolution, ultimately leading to more accurate and precise analytical results. In addition, MSTFA derivatization can help minimize unwanted interactions between compounds and GC columns, resulting in a more robust and reproducible analytical method.
