Dimethyl Sulfoxide for Headspace GC

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Name Dimethyl Sulfoxide for Headspace GC
Brand Sigma-Aldrich
Quantity 100 mL
Product Type Solvent
Purity 99.9%
Grade GC-HS
Cas Number 67-68-5
Density 1.10 g/mL at 25°C
Boiling Point 189°C
Flash Point 85°C
Appearance Clear liquid
Odor Characteristic
Storage Conditions Store at room temperature
Shelf Life 2 years
Applications Used as a solvent in gas chromatography, pharmaceuticals, and chemical research
Molecular Formula C2H6OS
Molar Mass 78.13 g/mol
FAQ
What is Dimethyl Sulfoxide (DMSO) and how is it used in Headspace GC analysis?

Dimethyl sulfoxide (DMSO) is a commonly used solvent in chromatography, including Headspace Gas Chromatography (GC). It is a versatile solvent that can dissolve a wide range of compounds, making it useful for sample preparation in various analytical techniques. In Headspace GC analysis, DMSO can be used to help improve the sensitivity and detection of volatile organic compounds (VOCs) in samples.

How does DMSO improve the performance of a Headspace GC analysis?

DMSO can improve the performance of a Headspace GC analysis in several ways. Firstly, it can help to dissolve and release volatile compounds from solid or liquid samples, allowing for better detection and quantification of VOCs. Additionally, DMSO has a high boiling point, which can aid in the vaporization and transfer of VOCs from the sample matrix to the gas phase for analysis. This can result in improved peak shapes, sensitivity, and reproducibility in Headspace GC analysis.

What are the benefits of using DMSO for Headspace GC analysis?

Some of the key benefits of using DMSO for Headspace GC analysis include its ability to solubilize a wide range of compounds, its high boiling point which aids in sample vaporization, and its compatibility with various sample matrices. DMSO can also help to improve the sensitivity and detection limits of VOCs in samples, leading to more accurate and reliable analytical results.

Are there any considerations or limitations when using DMSO for Headspace GC analysis?

While DMSO is a versatile solvent for Headspace GC analysis, there are some considerations and limitations to keep in mind. For example, DMSO has a distinctive odor that can interfere with the analysis of certain compounds. It is important to ensure that the use of DMSO does not affect the separation or detection of target compounds in the sample. Additionally, DMSO can interact with certain analytes or sample components, so it is important to optimize the method parameters to minimize any potential interferences.

How can I incorporate DMSO into my Headspace GC analysis workflow?

Incorporating DMSO into your Headspace GC analysis workflow is relatively straightforward. You can add a small volume of DMSO to your sample vial before sealing it for headspace analysis. Alternatively, you can use DMSO as a diluent or extraction solvent for sample preparation before injection into the Headspace GC system. By optimizing the concentration of DMSO and other method parameters, you can achieve improved sensitivity and performance in your Headspace GC analysis.
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